Abstract
Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc. This suggests that c-fos induction is a primary event and the earliest known effect on gene expression by growth factors.
MeSH terms
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Animals
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Cell Division / drug effects*
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Cell Transformation, Viral / drug effects
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Cycloheximide / pharmacology
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Epidermal Growth Factor / pharmacology
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Fibroblast Growth Factors / pharmacology
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Gene Expression Regulation / drug effects
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Growth Substances / pharmacology*
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Kinetics
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Mice
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Oncogenes*
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Platelet-Derived Growth Factor / pharmacology
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Transcription, Genetic / drug effects
Substances
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Growth Substances
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Platelet-Derived Growth Factor
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Fibroblast Growth Factors
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Epidermal Growth Factor
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Cycloheximide