Abstract
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Calcitonin / genetics*
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DNA / analysis
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DNA Restriction Enzymes
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Gene Expression Regulation*
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Genes
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Hypothalamus / metabolism
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Models, Biological
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Nucleic Acid Hybridization
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Protein Biosynthesis
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RNA Splicing*
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RNA, Heterogeneous Nuclear / analysis
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RNA, Messenger / genetics
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Rats
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Thyroid Gland / metabolism
Substances
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RNA, Heterogeneous Nuclear
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RNA, Messenger
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Calcitonin
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DNA
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DNA Restriction Enzymes
Associated data
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GENBANK/J00707
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GENBANK/J00708
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GENBANK/J00709
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GENBANK/J00714
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GENBANK/L00109
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GENBANK/L00110
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GENBANK/L00111
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GENBANK/N00001
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GENBANK/N00002
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GENBANK/N00015
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GENBANK/N00016