Depression of calcium transport in sarcoplasmic reticulum from diabetic rats: lack of involvement by specific regulatory mediators

Gen Pharmacol. 1984;15(1):1-5. doi: 10.1016/0306-3623(84)90071-5.

Abstract

Cardiac sarcoplasmic reticulum (SR) ATP-dependent Ca2+-uptake was found to be depressed in 4 month streptozotocin-induced diabetic rats. Calmodulin, cAMP-dependent protein kinase and K+ stimulated Ca2+-uptake to similar degrees in SR from both control diabetic rats. Long chain acylcarnitine (7 microM) decreased Ca2+-transport in control rats by 46% but only 26% in diabetic animals. The data suggests that the depression in cardiac SR Ca2+-uptake activity in diabetic rats is non-specific in origin and not a result of alterations in regulation of SR function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Biological Transport, Active / drug effects
  • Calcium / metabolism*
  • Calmodulin / pharmacology
  • Diabetes Mellitus, Experimental / metabolism*
  • Female
  • In Vitro Techniques
  • Myocardium / metabolism*
  • Potassium Chloride / pharmacology
  • Protein Kinases / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Sarcoplasmic Reticulum / metabolism*
  • Streptozocin

Substances

  • Calmodulin
  • Streptozocin
  • Potassium Chloride
  • Adenosine Triphosphate
  • Protein Kinases
  • Calcium