Abstract
Repetitious opening and closing of the mouth and high frequency clonic jaw movements were observed in rats challenged with dopamine agonists after acute treatment with sulpiride or a low dose of spiroperidol. SKF 38393, a specific D1 receptor agonist, alone, also induced these behaviors and cis-flupenthixol blocked them, evidence suggesting D1 dopamine receptor mediation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Animals
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Apomorphine / pharmacology
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Benzazepines / pharmacology
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Dyskinesia, Drug-Induced / etiology*
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Male
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects*
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Spiperone / pharmacology
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Sulpiride / pharmacology
Substances
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Benzazepines
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Spiperone
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Sulpiride
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Apomorphine