Abstract
Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very important role in the regulation of the functions of GABAergic transmission in the central nervous system.
MeSH terms
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Animals
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Brain / metabolism*
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Estrogens / pharmacology*
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Female
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In Vitro Techniques
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Isoxazoles
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Kinetics
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Muscimol / metabolism
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Nerve Tissue Proteins / metabolism
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Olfactory Bulb / metabolism
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Progesterone / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, GABA-A / drug effects*
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Receptors, GABA-A / metabolism
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Receptors, Neurotransmitter / drug effects*
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gamma-Aminobutyric Acid / metabolism
Substances
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Estrogens
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Isoxazoles
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Nerve Tissue Proteins
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Receptors, GABA-A
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Receptors, Neurotransmitter
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Muscimol
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Progesterone
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gamma-Aminobutyric Acid
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isothaz