Abstract
The acute effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) on mouse central monoaminergic neurons were investigated. In striatum, two hours after the injection of NMPTP (50 mg/kg s.c.) there was a seven-fold increase in 3-methoxytyramine that coincided with a 55% decrease in dopamine. In addition, the same dose of NMPTP caused an acute increase in mouse motor activity; this effect was antagonized by haloperidol or by pretreatment with reserpine. These data indicate that NMPTP initially causes a pronounced release of dopamine into the extraneuronal space.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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3,4-Dihydroxyphenylacetic Acid / analysis
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Animals
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Corpus Striatum / analysis
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Corpus Striatum / drug effects*
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Dopamine / analogs & derivatives*
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Dopamine / analysis*
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Homovanillic Acid / analysis
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Hydroxyindoleacetic Acid / analysis
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Male
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Mice
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Motor Activity / drug effects*
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Pyridines / pharmacology*
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Serotonin / analysis
Substances
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Pyridines
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3,4-Dihydroxyphenylacetic Acid
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Serotonin
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Hydroxyindoleacetic Acid
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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3-methoxytyramine
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Dopamine
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Homovanillic Acid