Destruction of cytochrome P-450 by 2-isopropyl-4-pentenamide and methyl 2-isopropyl-4-pentenoate: mass spectrometric characterization of prosthetic heme adducts and nonparticipation of epoxide metabolites

Arch Biochem Biophys. 1979 Oct 15;197(2):524-33. doi: 10.1016/0003-9861(79)90276-5.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetamides / pharmacology*
  • Allylisopropylacetamide / pharmacology*
  • Animals
  • Cytochrome P-450 Enzyme System / metabolism*
  • Epoxy Compounds / metabolism
  • Fatty Acids, Monounsaturated
  • Fatty Acids, Unsaturated / pharmacology*
  • Liver / drug effects
  • Mass Spectrometry
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • NADP / pharmacology
  • Phenobarbital / pharmacology
  • Porphyrins / biosynthesis
  • Rats

Substances

  • Acetamides
  • Epoxy Compounds
  • Fatty Acids, Monounsaturated
  • Fatty Acids, Unsaturated
  • Porphyrins
  • Allylisopropylacetamide
  • NADP
  • methyl 2-isopropyl-4-pentenoate
  • Cytochrome P-450 Enzyme System
  • Phenobarbital