Abstract
1. The pharmacological activities of the optical isomers of salbutamol have been examined. (-)-Salbutamol was much more potent than (+)-salbutamol on beta-adrenoceptors.2. Both (-)- and (+)-salbutamol showed high selectivity for beta-adrenoceptors in bronchial muscle compared to cardiac muscle, in this way resembling racemic salbutamol.3. The use of isomeric activity ratio to detect differences between receptors was examined in the light of the results obtained with the isomers of salbutamol.
MeSH terms
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Adrenergic beta-Agonists / pharmacology*
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Airway Resistance / drug effects
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Animals
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Blood Pressure / drug effects
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Bronchi / drug effects
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Butylamines / pharmacology
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Dose-Response Relationship, Drug
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Ethanolamines / pharmacology*
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Guinea Pigs
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Heart Rate / drug effects
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In Vitro Techniques
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Isomerism
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Isoproterenol / pharmacology
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Phenethylamines / pharmacology*
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Propranolol / pharmacology
Substances
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Adrenergic beta-Agonists
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Butylamines
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Ethanolamines
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Phenethylamines
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Propranolol
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Isoproterenol