Abstract
Prostacyclin and thromboxane A2 are products of arachidonic acid which play a role in the regulation of haemostatic plug and thrombus formation. Aspirin inhibits the synthesis of both compounds but is more active in blocking TXA2 formation; based on this, aspirin is suggested to have an anti-thrombotic effect. Other possible approaches to the development of anti-thrombotic drugs are discussed.
MeSH terms
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Animals
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Aspirin / pharmacology
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Blood Platelets / metabolism
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Blood Platelets / physiology*
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Dose-Response Relationship, Drug
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Epoprostenol / metabolism*
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Humans
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Platelet Aggregation
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Prostaglandins / metabolism*
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Thrombosis / metabolism
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Thrombosis / physiopathology*
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Thromboxane A2 / metabolism*
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Thromboxanes / metabolism*
Substances
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Prostaglandins
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Thromboxanes
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Thromboxane A2
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Epoprostenol
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Aspirin