Abstract
In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylcholine / metabolism
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Aged
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Alzheimer Disease / drug therapy
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Alzheimer Disease / enzymology
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Alzheimer Disease / metabolism*
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Cerebral Cortex / analysis*
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Cerebral Cortex / enzymology
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Cerebral Cortex / metabolism
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Choline O-Acetyltransferase / metabolism*
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Humans
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Nicotine / metabolism
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Receptors, Nicotinic / analysis*
Substances
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Receptors, Nicotinic
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Nicotine
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Choline O-Acetyltransferase
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Acetylcholine