Is the forced swimming test a suitable model for revealing antidepressant activity?

F Borsini; A Meli

doi:10.1007/BF00176837

Is the forced swimming test a suitable model for revealing antidepressant activity?

Psychopharmacology (Berl). 1988;94(2):147-60. doi: 10.1007/BF00176837.

Authors

F Borsini¹, A Meli

Affiliation

¹ A. Menarini Pharmaceuticals, Research Department, Firenze, Italy.

PMID: 3127840
DOI: 10.1007/BF00176837

Abstract

The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species.

Publication types

Review

MeSH terms

Animals
Antidepressive Agents / pharmacology*
Depression / drug therapy*
Depression / physiopathology
Disease Models, Animal*
Mice
Physical Exertion*
Rats
Species Specificity
Swimming

Substances

Antidepressive Agents