Abstract
Phosphatidylinositol metabolism and 45Ca2+ efflux were examined in a vascular smooth muscle cell line (A7r5). [Arg 8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates was similar to that for 45Ca2+ efflux from preloaded cells. The efflux of 45Ca2+ in response to [Arg8]vasopressin could be inhibited by a vasopressin antagonist. This supports the hypothesis that inositol 1,4,5-trisphosphate plays a role in vasopressin stimulated calcium mobilisation from an intracellular source in cultured vascular smooth muscle cells.
MeSH terms
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Animals
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Arginine Vasopressin / analogs & derivatives
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Arginine Vasopressin / antagonists & inhibitors
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Arginine Vasopressin / pharmacology*
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Calcium / metabolism*
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Calcium Radioisotopes / metabolism
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Cell Line
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Chlorides / pharmacology
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Inositol 1,4,5-Trisphosphate
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Inositol Phosphates / biosynthesis*
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Kinetics
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Lithium / pharmacology
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Lithium Chloride
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / metabolism*
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Rats
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Sugar Phosphates / biosynthesis*
Substances
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Calcium Radioisotopes
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Chlorides
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Inositol Phosphates
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Sugar Phosphates
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Arginine Vasopressin
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argipressin, beta-mercapto beta,beta-cyclopentamethylenepropionic acid(1)-O-methyl-Tyr(2)-Val(4)-
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Inositol 1,4,5-Trisphosphate
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Lithium
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Lithium Chloride
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Calcium