Abstract
2-Amino-5-phosphonovalerate (APV, icv) phencyclidine (PCP, ip) and scopolamine (sc) dose-dependently disrupted short term working memory in radial maze. These drugs injected before, but not after training attenuated retention of long term memory in passive avoidance task. A relation of PCP action to its antagonism at NMDA receptors may be suggested.
MeSH terms
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2-Amino-5-phosphonovalerate
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Animals
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Anticonvulsants / administration & dosage
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Anticonvulsants / pharmacology*
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Avoidance Learning / drug effects
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Injections, Intraventricular
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Learning / drug effects*
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Male
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Phencyclidine / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter / drug effects*
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Scopolamine / pharmacology*
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Valine / administration & dosage
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Valine / analogs & derivatives*
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Valine / pharmacology
Substances
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Anticonvulsants
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter
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2-Amino-5-phosphonovalerate
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Scopolamine
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Valine
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Phencyclidine