Abstract
1. Pharmacological properties of a new antitumor drug, CPT-11, were studied in some muscle preparations. 2. CPT-11 induced contraction of guinea-pig ileal and tracheal preparations, which was blocked by atropine (10(-6) M). 3. CPT-11 potentiated the contractile responses of guinea-pig ileum to acetylcholine, nicotine, serotonin and BaCl2. 4. The chronic and inotropic effects induced by isoprenaline were depressed by CPT-11. 5. These results suggest that CPT-11 has an acetylcholine action.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Aorta, Thoracic / drug effects
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Camptothecin / analogs & derivatives*
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Camptothecin / pharmacology
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Female
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Guinea Pigs
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Heart / drug effects
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Ileum / drug effects
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In Vitro Techniques
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Irinotecan
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Male
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Muscle, Smooth / drug effects*
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Muscle, Smooth, Vascular / drug effects
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Rabbits
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Rats
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Rats, Inbred Strains
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Trachea / drug effects
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Uterine Contraction / drug effects
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Vas Deferens / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Irinotecan
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Camptothecin