Some pharmacological properties of a new antitumor drug, CPT-11, in isolated muscle preparations

I Takayanagi; K Koike; M Tagawa; E Mitsuhashi

doi:10.1016/0306-3623(89)90326-1

Some pharmacological properties of a new antitumor drug, CPT-11, in isolated muscle preparations

Gen Pharmacol. 1989;20(6):763-6. doi: 10.1016/0306-3623(89)90326-1.

Authors

I Takayanagi¹, K Koike, M Tagawa, E Mitsuhashi

Affiliation

¹ Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.

PMID: 2591705
DOI: 10.1016/0306-3623(89)90326-1

Abstract

1. Pharmacological properties of a new antitumor drug, CPT-11, were studied in some muscle preparations. 2. CPT-11 induced contraction of guinea-pig ileal and tracheal preparations, which was blocked by atropine (10(-6) M). 3. CPT-11 potentiated the contractile responses of guinea-pig ileum to acetylcholine, nicotine, serotonin and BaCl2. 4. The chronic and inotropic effects induced by isoprenaline were depressed by CPT-11. 5. These results suggest that CPT-11 has an acetylcholine action.

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / pharmacology*
Aorta, Thoracic / drug effects
Camptothecin / analogs & derivatives*
Camptothecin / pharmacology
Female
Guinea Pigs
Heart / drug effects
Ileum / drug effects
In Vitro Techniques
Irinotecan
Male
Muscle, Smooth / drug effects*
Muscle, Smooth, Vascular / drug effects
Rabbits
Rats
Rats, Inbred Strains
Trachea / drug effects
Uterine Contraction / drug effects
Vas Deferens / drug effects

Substances

Antineoplastic Agents, Phytogenic
Irinotecan
Camptothecin