Neutrophils in asthma--a review

Olga Ciepiela; Magdalena Ostafin; Urszula Demkow

doi:10.1016/j.resp.2014.12.004

Neutrophils in asthma--a review

Respir Physiol Neurobiol. 2015 Apr:209:13-6. doi: 10.1016/j.resp.2014.12.004. Epub 2014 Dec 12.

Authors

Olga Ciepiela¹, Magdalena Ostafin², Urszula Demkow²

Affiliations

¹ Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Marszałkowska 24, 00-576 Warsaw, Poland. Electronic address: olga.ciepiela@wum.edu.pl.
² Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Marszałkowska 24, 00-576 Warsaw, Poland.

PMID: 25511380
DOI: 10.1016/j.resp.2014.12.004

Abstract

Asthma is a chronic inflammatory disease, with an array of cells involved in the pathogenesis of the disease. The role of neutrophils in the development of bronchial asthma is found to be complex, as they may trigger activation of immunocompetent cells and are a potent source of free oxygen radicals and enzymes participating in airway remodeling. The review highlights the role of neutrophils in bronchial asthma.

Keywords: Asthma; Interleukin 8; Neutrophil; Neutrophil extracellular trap.

Publication types

Review

MeSH terms

Apoptosis / physiology
Asthma / physiopathology*
Cytokines / metabolism
Extracellular Matrix / metabolism
Humans
Neutrophils / physiology*

Substances

Cytokines