Abstract
The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Calcium / metabolism
-
Ion Channels / analysis*
-
Ion Channels / metabolism
-
Ion Channels / ultrastructure
-
Liposomes
-
Membrane Potentials
-
Rabbits
-
Receptors, Cholinergic / isolation & purification*
-
Receptors, Cholinergic / metabolism
-
Ryanodine Receptor Calcium Release Channel
-
Sarcoplasmic Reticulum / analysis*
-
Sarcoplasmic Reticulum / ultrastructure
Substances
-
Ion Channels
-
Liposomes
-
Receptors, Cholinergic
-
Ryanodine Receptor Calcium Release Channel
-
Calcium