The ability of des-Arg9-bradykinin to relax rabbit isolated mesenteric arteries is acquired during in vitro incubation

Eur J Pharmacol. 1987 Oct 6;142(1):141-4. doi: 10.1016/0014-2999(87)90664-9.

Abstract

Strips of rabbit mesenteric arteries precontracted with phenylephrine relaxed when exposed to des-Arg9-bradykinin (BK), a typical B1 receptor agonist. We showed that the ability of des-Arg9-BK to relax this preparation was acquired during in vitro incubation and was abolished by cycloheximide treatment. In this preparation intimal damage reduced but did not abolish the relaxant effect of des-Arg9-BK, and indomethacin uncovered a contractile effect of des-Arg9-BK also acquired during the in vitro incubation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bradykinin / analogs & derivatives*
  • Bradykinin / pharmacology
  • Cycloheximide / pharmacology
  • Endothelium, Vascular / physiology
  • Female
  • In Vitro Techniques
  • Male
  • Mesenteric Arteries / drug effects
  • Muscle Relaxation / drug effects
  • Muscle, Smooth, Vascular / drug effects*
  • Phenylephrine / pharmacology
  • Rabbits
  • Substance P / pharmacology

Substances

  • bradykinin, des-Arg(9)-
  • Phenylephrine
  • Substance P
  • Cycloheximide
  • Bradykinin