Abstract
Yang et al. (14) have isolated from mammalian brain an octapeptide FLFQPQRF-NH2 (F-8-F-NH2) with certain antiopiate properties. Third ventricular injection of 2 micrograms of this peptide together with the aminopeptidase inhibitor bestatin precipitated an opiate-withdrawal syndrome in morphine-dependent but not in nondependent rats. Third ventricular injection in nondependent rats of 15 micrograms of the peptide together with bestatin induced a morphine-withdrawal-like behavioral syndrome. This syndrome was not produced by injection of bestatin or saline vehicle alone and was preventable by injection of 3.5 mg/kg morphine sulphate SC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Double-Blind Method
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Injections, Intraventricular
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Leucine / analogs & derivatives
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Leucine / pharmacology
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Male
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Morphine / adverse effects*
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Morphine / pharmacology
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Neuropeptides / administration & dosage
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Neuropeptides / antagonists & inhibitors
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Neuropeptides / pharmacology*
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Oligopeptides / administration & dosage
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Oligopeptides / antagonists & inhibitors
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Oligopeptides / pharmacology*
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Random Allocation
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Rats
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Rats, Inbred Strains
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Substance Withdrawal Syndrome / etiology*
Substances
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Neuropeptides
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Oligopeptides
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Morphine
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phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
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Leucine
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ubenimex