Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries

N Toda; T Okamura

doi:10.1254/jjp.52.170

Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries

Jpn J Pharmacol. 1990 Jan;52(1):170-3. doi: 10.1254/jjp.52.170.

Authors

N Toda¹, T Okamura

Affiliation

¹ Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.

PMID: 2308238
DOI: 10.1254/jjp.52.170

Abstract

Treatment with L-NG-monomethyl arginine (L-NMMA) increased the vasoconstriction induced by adrenergic nerve stimulation in perfused dog mesenteric artery segments and suppressed the relaxant response to transmural nerve stimulation in dog cerebral artery strips, the effects of L-NMMA being reversed by L-arginine. The observed changes in nerve function may be associated with the inhibition of synthesis of nitric oxide.

MeSH terms

Animals
Arginine / analogs & derivatives*
Arginine / pharmacology
Blood Pressure / drug effects
Cerebral Arteries / drug effects
Dinoprost / pharmacology
Dogs
Electric Stimulation
In Vitro Techniques
Mesenteric Arteries / drug effects
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*
Muscle, Smooth, Vascular / physiology
omega-N-Methylarginine

Substances

omega-N-Methylarginine
Arginine
Dinoprost