Intracerebroventricular injection of hemicholinium-3 prevents the ACTH-induced, but not the physostigmine-induced, reversal of hemorrhagic shock in rats

S Guarini; S Tagliavini; C Bazzani; F Ferrante; A Bertolini

doi:10.1159/000138645

Intracerebroventricular injection of hemicholinium-3 prevents the ACTH-induced, but not the physostigmine-induced, reversal of hemorrhagic shock in rats

Pharmacology. 1990;40(2):85-9. doi: 10.1159/000138645.

Authors

S Guarini¹, S Tagliavini, C Bazzani, F Ferrante, A Bertolini

Affiliation

¹ Institute of Pharmacology, University of Modena, Italy.

PMID: 2161112
DOI: 10.1159/000138645

Abstract

In rats bled to hypovolemic shock, the intracerebroventricular injection of hemicholinium-3 (20 micrograms/rat) completely prevented the shock reversal induced by the intravenous injection of ACTH (1-24) (160 micrograms/kg), but had no influence on the shock reversal induced by the intravenous injection of physostigmine (70 micrograms/kg). These data indicate that brain cholinergic neurons are involved in the anti-shock effect of ACTH-peptides, but not in that of centrally acting cholinergic drugs.

MeSH terms

Adrenocorticotropic Hormone / antagonists & inhibitors*
Adrenocorticotropic Hormone / pharmacology
Animals
Blood Pressure / drug effects
Disease Models, Animal
Female
Heart Rate / drug effects
Hemicholinium 3 / administration & dosage
Hemicholinium 3 / pharmacology*
Injections, Intravenous
Injections, Intraventricular
Male
Physostigmine / antagonists & inhibitors*
Physostigmine / pharmacology
Rats
Rats, Inbred Strains
Respiration / drug effects
Shock, Hemorrhagic / drug therapy*

Substances

Hemicholinium 3
Adrenocorticotropic Hormone
Physostigmine