Abstract
The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carcinogens
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Cell Extracts
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Cells / drug effects
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Diarrhea / etiology
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Ethers, Cyclic* / metabolism
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Ethers, Cyclic* / pharmacology
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Ethers, Cyclic* / toxicity
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Humans
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Marine Toxins
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Okadaic Acid
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Oxazoles / pharmacology
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Oxazoles / toxicity
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Phosphoprotein Phosphatases / analysis
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Phosphoprotein Phosphatases / antagonists & inhibitors
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Phosphorylation
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Shellfish Poisoning
Substances
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Carcinogens
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Cell Extracts
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Ethers, Cyclic
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Marine Toxins
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Oxazoles
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Okadaic Acid
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calyculin A
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Phosphoprotein Phosphatases