Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

M Bianchi; A Mantovani; A Erroi; C A Dinarello; P Ghezzi

doi:10.1007/BF01997619

Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

Agents Actions. 1990 Nov;31(3-4):275-9. doi: 10.1007/BF01997619.

Authors

M Bianchi¹, A Mantovani, A Erroi, C A Dinarello, P Ghezzi

Affiliation

¹ Laboratory of Immunology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

PMID: 2085143
DOI: 10.1007/BF01997619

Abstract

We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 microgram ml, without any apparent toxicity.

MeSH terms

Ambroxol / pharmacology*
Cells, Cultured
Escherichia coli
Humans
Interleukin-1 / blood*
Interleukin-1 / genetics
Leukocytes, Mononuclear / drug effects
Leukocytes, Mononuclear / metabolism*
Lipopolysaccharides / pharmacology
RNA, Messenger / metabolism
Tumor Necrosis Factor-alpha / biosynthesis*

Substances

Interleukin-1
Lipopolysaccharides
RNA, Messenger
Tumor Necrosis Factor-alpha
Ambroxol