Abstract
The effects of an acute low dose of haloperidol on neurotensin mRNA-containing cells in rat forebrain was studied using in situ hybridization histochemistry. Within 1 h of a single dose of haloperidol (0.5 mg/kg) a nearly 3-fold increase in the number of cells that express the neurotensin/neuromedin N-encoding mRNA was observed in the dorsolateral striatum. However, the number of hybridization-positive cells did not appear to be affected in the nucleus accumbens, or the septal nuclei following treatment with the neuroleptic.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoradiography
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Corpus Striatum / drug effects
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Corpus Striatum / physiology*
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Gene Expression / drug effects
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Haloperidol / pharmacology*
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Male
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Neurons / drug effects
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Neurons / physiology*
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Neurotensin / genetics*
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Nucleic Acid Hybridization
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RNA Probes
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RNA, Messenger / analysis
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RNA, Messenger / drug effects
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RNA, Messenger / genetics*
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Rats
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Rats, Inbred Strains
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Reference Values
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Sulfur Radioisotopes
Substances
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RNA Probes
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RNA, Messenger
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Sulfur Radioisotopes
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Neurotensin
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Haloperidol