Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic

J Med Chem. 2010 Jun 24;53(12):4561-84. doi: 10.1021/jm100012m.
No abstract available

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Binding Sites
  • Drug Discovery
  • Drug Industry
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / history
  • Enzyme Inhibitors / pharmacology
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Ischemia / drug therapy
  • Ischemia / enzymology
  • Niacinamide / metabolism
  • Poly(ADP-ribose) Polymerase Inhibitors*
  • Research

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Niacinamide