Abstract
The histamine H4 receptor is expressed preferentially on immune cells, indicating a possible role of the H4 receptor in inflammation. Studies of inflammation in several animal models point to a pro-inflammatory function of the H4 receptor. However, studies on experimental murine bronchial asthma yielded conflicting results, a fact which is neglected in most H4 receptor publications. Therefore, the present review critically analyzes available data on the role of the H4 receptor in the murine bronchial asthma model.
2010 S. Karger AG, Basel.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Asthma / physiopathology*
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Disease Models, Animal
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Histamine / physiology
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Humans
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Indoles / pharmacology
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Inflammation / physiopathology
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Mice
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Piperazines / pharmacology
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Receptors, G-Protein-Coupled / drug effects
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Receptors, G-Protein-Coupled / physiology*
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Receptors, Histamine / drug effects
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Receptors, Histamine / physiology*
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Receptors, Histamine H3 / physiology
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Receptors, Histamine H4
Substances
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Hrh4 protein, mouse
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Indoles
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Piperazines
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Receptors, G-Protein-Coupled
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Receptors, Histamine
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Receptors, Histamine H3
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Receptors, Histamine H4
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1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine
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Histamine