Abstract
The complement system is important for cellular integrity and tissue homeostasis. Complement activation mediates the removal of microorganisms and the clearance of modified self cells, such as apoptotic cells. Complement regulators control the spontaneously activated complement cascade and any disturbances in this delicate balance can result in damage to tissues and in autoimmune disease. Therefore, insights into the mechanisms of complement regulation are crucial for understanding disease pathology and for enabling the development of diagnostic tools and therapies for complement-associated diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmune Diseases / immunology
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Autoimmune Diseases / metabolism
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Complement Activation / genetics
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Complement Activation / immunology*
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Complement C3-C5 Convertases / immunology*
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Complement C3-C5 Convertases / metabolism
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Complement Inactivator Proteins / immunology*
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Complement Inactivator Proteins / metabolism
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Glomerulonephritis, Membranoproliferative / immunology
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Glomerulonephritis, Membranoproliferative / metabolism
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Hemolytic-Uremic Syndrome / immunology
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Hemolytic-Uremic Syndrome / metabolism
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Humans
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Infections / immunology
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Infections / metabolism
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Macular Degeneration / immunology
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Macular Degeneration / metabolism
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Neoplasms / immunology
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Neoplasms / metabolism
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Receptors, Complement / immunology*
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Receptors, Complement / metabolism
Substances
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Complement Inactivator Proteins
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Receptors, Complement
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Complement C3-C5 Convertases