Abstract
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Division
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Cholesterol / biosynthesis
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Farnesol / metabolism
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Gene Expression Regulation / drug effects
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Humans
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Hydroxymethylglutaryl CoA Reductases / genetics
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Hydroxymethylglutaryl-CoA Synthase / genetics
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Mevalonic Acid / metabolism*
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Receptors, LDL / genetics
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Sterols / pharmacology
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Transcription, Genetic / drug effects
Substances
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Receptors, LDL
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Sterols
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Farnesol
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Cholesterol
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Hydroxymethylglutaryl CoA Reductases
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Hydroxymethylglutaryl-CoA Synthase
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Mevalonic Acid