The x(c)(-) cystine/glutamate antiporter (xCT) as a potential target for therapy of cancer: yet another cytotoxic anticancer approach?

J Cell Physiol. 2009 Aug;220(2):531-2; author reply 533-4. doi: 10.1002/jcp.21795.
No abstract available

Publication types

  • Comment
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Transport System y+ / genetics
  • Amino Acid Transport System y+ / metabolism*
  • Antineoplastic Agents / metabolism
  • Antiporters / genetics
  • Antiporters / metabolism*
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy*
  • Cystine / metabolism*
  • Glutamic Acid / metabolism*
  • Humans
  • Protein Subunits / genetics
  • Protein Subunits / metabolism

Substances

  • Amino Acid Transport System y+
  • Antineoplastic Agents
  • Antiporters
  • Protein Subunits
  • SLC7A11 protein, human
  • Glutamic Acid
  • Cystine