Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid

Biochem Pharmacol. 1991 Sep 12;42(7):1504-7. doi: 10.1016/0006-2952(91)90468-k.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Chlorambucil / metabolism*
  • Chromatography, High Pressure Liquid
  • Ethacrynic Acid / pharmacology*
  • Female
  • Glutathione / metabolism*
  • Glutathione Transferase / antagonists & inhibitors
  • Glutathione Transferase / isolation & purification
  • Glutathione Transferase / metabolism*
  • Humans
  • Inactivation, Metabolic
  • Isoelectric Focusing
  • Kinetics
  • Liver / enzymology
  • Mice
  • Ovary / enzymology

Substances

  • Chlorambucil
  • Glutathione Transferase
  • Glutathione
  • Ethacrynic Acid