Abstract
We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. Afobazole was far superior to the reference cerebroprotective drug cavinton (4 mg/kg) by neuroprotective activity.
MeSH terms
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Animals
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Anti-Anxiety Agents / administration & dosage
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Anti-Anxiety Agents / therapeutic use
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Benzimidazoles / administration & dosage
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Benzimidazoles / therapeutic use*
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Blood Vessels / pathology*
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Brain Ischemia / drug therapy*
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Brain Ischemia / pathology
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Injections, Intraperitoneal
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Light
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Male
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Mice
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Morpholines / administration & dosage
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Morpholines / therapeutic use*
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Motor Activity / physiology
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Neuroprotective Agents / administration & dosage
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Neuroprotective Agents / therapeutic use*
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Prefrontal Cortex / pathology*
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Rats
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Stroke / drug therapy*
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Stroke / pathology
Substances
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2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole
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Anti-Anxiety Agents
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Benzimidazoles
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Morpholines
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Neuroprotective Agents