Abstract
Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology
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Apoptosis / immunology
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Clonal Anergy / immunology
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Critical Illness
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Down-Regulation / immunology
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HLA-DR Antigens / blood
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Homeostasis / immunology*
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Humans
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Immune Tolerance / immunology*
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Immunity, Cellular / immunology*
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Inflammation Mediators / blood*
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Lymphocytes / immunology
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Monocytes / immunology
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Sepsis / immunology*
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Suppressor Factors, Immunologic / blood*
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Systemic Inflammatory Response Syndrome / immunology*
Substances
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HLA-DR Antigens
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Inflammation Mediators
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Suppressor Factors, Immunologic