VEGF receptor protein-tyrosine kinases: structure and regulation

Robert Roskoski Jr

doi:10.1016/j.bbrc.2008.07.121

VEGF receptor protein-tyrosine kinases: structure and regulation

Biochem Biophys Res Commun. 2008 Oct 24;375(3):287-91. doi: 10.1016/j.bbrc.2008.07.121. Epub 2008 Aug 3.

Author

Robert Roskoski Jr¹

Affiliation

¹ Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116A, Box 19, Horse Shoe, NC 28742, USA.

PMID: 18680722
DOI: 10.1016/j.bbrc.2008.07.121

Abstract

The human VEGF family consists of VEGF (VEGF-A), VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF). The VEGF family of receptors consists of three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2). These components participate in new blood vessel formation from angioblasts (vasculogenesis) and new blood vessel formation from pre-existing vasculature (angiogenesis). Interaction between VEGFR1 and VEGFR2 or VEGFR2 and VEGFR3 alters receptor tyrosine phosphorylation.

Publication types

Review

MeSH terms

Animals
Humans
Mice
Protein Conformation
Receptors, Vascular Endothelial Growth Factor / chemistry*
Receptors, Vascular Endothelial Growth Factor / classification
Receptors, Vascular Endothelial Growth Factor / metabolism*
Vascular Endothelial Growth Factor Receptor-1 / chemistry
Vascular Endothelial Growth Factor Receptor-1 / metabolism

Substances

Receptors, Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor Receptor-1