Abstract
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Brain / metabolism*
-
Cloning, Molecular
-
Electrophysiology
-
Ibotenic Acid / analogs & derivatives
-
Ibotenic Acid / chemistry
-
Kainic Acid / chemistry
-
Molecular Sequence Data
-
Molecular Structure
-
RNA, Messenger / analysis
-
Rats
-
Receptors, N-Methyl-D-Aspartate / genetics*
-
Xenopus / genetics
-
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Substances
-
RNA, Messenger
-
Receptors, N-Methyl-D-Aspartate
-
Ibotenic Acid
-
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
-
Kainic Acid