Abstract
Nitrous oxide antinociception in the abdominal constriction test was significantly reduced in mice pretreated intracerebroventricularly (i.c.v.) with beta-chlornaltrexamine (beta-CNA). However, this antagonism was reversed when the beta-CNA was co-administered i.c.v. with the kappa-opioid ligand U-50,488H but not the mu-opioid ligand CTOP. These findings further demonstrate that nitrous oxide antinociception in the mouse abdominal constriction paradigm is mediated by kappa- but not mu-opioid receptors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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Analgesia*
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Analgesics / pharmacology*
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Animals
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Fentanyl / analogs & derivatives
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Fentanyl / pharmacology
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Male
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Mice
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Mice, Inbred ICR
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Naltrexone / analogs & derivatives*
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Naltrexone / pharmacology
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Narcotic Antagonists / pharmacology*
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Nitrous Oxide / antagonists & inhibitors
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Nitrous Oxide / pharmacology*
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Pain / physiopathology*
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Pyrrolidines / pharmacology*
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Sufentanil
Substances
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Analgesics
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Narcotic Antagonists
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Pyrrolidines
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Naltrexone
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chlornaltrexamine
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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Sufentanil
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Nitrous Oxide
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Fentanyl