Abstract
To examine the role of GTP-binding proteins in amygdaloid (AM) kindling, pertussis toxin (PTX), which inhibits PTX-sensitive GTP-binding proteins through ADP-ribosylation, was injected into the stimulated AM of fully kindled rats. Intra-AM injections of PTX strongly suppressed kindled seizures. The significant seizure suppression began 2 days after the injection, lasted 4 days, and was due to an increase in afterdischarge threshold. The results suggest that PTX-sensitive GTP-binding proteins in the stimulated site play a significant role in the induction of kindled seizures.
MeSH terms
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Adenosine Diphosphate Ribose / metabolism
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Amygdala / drug effects
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Amygdala / physiopathology*
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Animals
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Electric Stimulation
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GTP-Binding Proteins / antagonists & inhibitors
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GTP-Binding Proteins / metabolism
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GTP-Binding Proteins / physiology*
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Kindling, Neurologic / drug effects
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Kindling, Neurologic / physiology*
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Male
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Pertussis Toxin*
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Protein Processing, Post-Translational / drug effects
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Rats
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Rats, Inbred Strains
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Second Messenger Systems / drug effects*
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Seizures / physiopathology*
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Virulence Factors, Bordetella / pharmacology*
Substances
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Virulence Factors, Bordetella
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Adenosine Diphosphate Ribose
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Pertussis Toxin
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GTP-Binding Proteins