Abstract
Emerging data reveal that besides degrading proteins tagged with ubiquitin, the proteasome plays a more varied and decisive role in cellular regulation than previously imagined. In this issue, Hanna et al. (2007) expand our view of the proteasome by showing that under certain conditions, proteasome composition can be altered to control ubiquitin homeostasis.
MeSH terms
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Animals
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Homeostasis / physiology*
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Humans
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Macromolecular Substances / metabolism
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Proteasome Endopeptidase Complex / metabolism*
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Proteasome Endopeptidase Complex / ultrastructure
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Protein Binding / physiology
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Proteins / metabolism*
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Ubiquitin / metabolism*
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Ubiquitin-Protein Ligase Complexes / metabolism
Substances
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Macromolecular Substances
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PA700 proteasome activator
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Proteins
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Ubiquitin
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Ubiquitin-Protein Ligase Complexes
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Proteasome Endopeptidase Complex