Proteasomes: machines for all reasons

Cell. 2007 May 18;129(4):659-62. doi: 10.1016/j.cell.2007.05.007.

Abstract

Emerging data reveal that besides degrading proteins tagged with ubiquitin, the proteasome plays a more varied and decisive role in cellular regulation than previously imagined. In this issue, Hanna et al. (2007) expand our view of the proteasome by showing that under certain conditions, proteasome composition can be altered to control ubiquitin homeostasis.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Homeostasis / physiology*
  • Humans
  • Macromolecular Substances / metabolism
  • Proteasome Endopeptidase Complex / metabolism*
  • Proteasome Endopeptidase Complex / ultrastructure
  • Protein Binding / physiology
  • Proteins / metabolism*
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligase Complexes / metabolism

Substances

  • Macromolecular Substances
  • PA700 proteasome activator
  • Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Proteasome Endopeptidase Complex