The effects of superoxide dismutase on H2O2 formation

Stefan I Liochev; Irwin Fridovich

doi:10.1016/j.freeradbiomed.2007.02.015

The effects of superoxide dismutase on H2O2 formation

Free Radic Biol Med. 2007 May 15;42(10):1465-9. doi: 10.1016/j.freeradbiomed.2007.02.015. Epub 2007 Feb 28.

Authors

Stefan I Liochev¹, Irwin Fridovich

Affiliation

¹ Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

PMID: 17448892
DOI: 10.1016/j.freeradbiomed.2007.02.015

Abstract

Numerous reports of the effects of overproduction of SODs have been explained on the basis of increased H2O2 production by the catalyzed dismutation of O2-. In this review we consider the effects of increasing [SOD] on H2O2 formation and question this explanation.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Hydrogen Peroxide / metabolism*
Superoxide Dismutase / metabolism*

Substances

Hydrogen Peroxide
Superoxide Dismutase

Grants and funding

R21-ES013682/ES/NIEHS NIH HHS/United States