Post-translational modifications regulate the ticking of the circadian clock

Nat Rev Mol Cell Biol. 2007 Feb;8(2):139-48. doi: 10.1038/nrm2106.

Abstract

Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during late afternoon seminars. Our internal clocks control these and many more workings of the body, and disruptions of the circadian clocks predispose individuals to depression, obesity and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Chronobiology Disorders / etiology
  • Circadian Rhythm*
  • Drosophila melanogaster / enzymology
  • Drosophila melanogaster / metabolism
  • Drosophila melanogaster / physiology*
  • Feedback, Physiological
  • Gene Expression Regulation*
  • Humans
  • Neurospora crassa / enzymology
  • Neurospora crassa / physiology*
  • Phosphoric Monoester Hydrolases / metabolism
  • Phosphoric Monoester Hydrolases / physiology
  • Phosphorylation
  • Phosphotransferases / metabolism
  • Phosphotransferases / physiology
  • Protein Processing, Post-Translational*
  • Signal Transduction

Substances

  • Phosphotransferases
  • Phosphoric Monoester Hydrolases