Abstract
The discovery of JP-1302 as a selective, high affinity antagonist at the alpha2C-adrenoceptor will enable researchers to probe the functional role and address the therapeutic utility of this potentially highly important adrenoceptor subtype.
MeSH terms
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Acridines*
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Adrenergic alpha-Antagonists*
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Animals
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Animals, Genetically Modified
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Brain Chemistry / drug effects
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Brain Chemistry / physiology*
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Mice
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Piperazines*
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Rats
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Rats, Sprague-Dawley
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Rats, Wistar
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Receptors, Adrenergic, alpha-2 / drug effects
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Receptors, Adrenergic, alpha-2 / physiology*
Substances
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Acridines
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Adra2c protein, mouse
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Adrenergic alpha-Antagonists
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JP-1302
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Piperazines
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Receptors, Adrenergic, alpha-2