JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain

Br J Pharmacol. 2007 Feb;150(4):381-2. doi: 10.1038/sj.bjp.0707007. Epub 2007 Jan 15.

Abstract

The discovery of JP-1302 as a selective, high affinity antagonist at the alpha2C-adrenoceptor will enable researchers to probe the functional role and address the therapeutic utility of this potentially highly important adrenoceptor subtype.

Publication types

  • Comment

MeSH terms

  • Acridines*
  • Adrenergic alpha-Antagonists*
  • Animals
  • Animals, Genetically Modified
  • Brain Chemistry / drug effects
  • Brain Chemistry / physiology*
  • Mice
  • Piperazines*
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Receptors, Adrenergic, alpha-2 / drug effects
  • Receptors, Adrenergic, alpha-2 / physiology*

Substances

  • Acridines
  • Adra2c protein, mouse
  • Adrenergic alpha-Antagonists
  • JP-1302
  • Piperazines
  • Receptors, Adrenergic, alpha-2