Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase

MeSH terms

• Adenosine Triphosphate / metabolism
• Agammaglobulinaemia Tyrosine Kinase
• Amino Acid Sequence
• Animals
• Antirheumatic Agents / chemistry
• Antirheumatic Agents / pharmacology*
• Antirheumatic Agents / therapeutic use
• Arthritis, Rheumatoid / drug therapy
• Arthritis, Rheumatoid / enzymology
• Binding Sites
• Disease Models, Animal
• Drug Design*
• Molecular Sequence Data
• Oligopeptides / chemistry
• Oligopeptides / metabolism
• Protein Kinase Inhibitors / chemistry
• Protein Kinase Inhibitors / pharmacology*
• Protein Kinase Inhibitors / therapeutic use
• Protein-Tyrosine Kinases / antagonists & inhibitors*
• Protein-Tyrosine Kinases / metabolism
• Rodentia
• Structure-Activity Relationship