Abstract
The hemodynamic effects of a series of potent and selective 4-aminopyridine carboxamide-based pan-JNK inhibitors were assessed in an anesthetized rat model. The effects of these agents on mean arterial pressure, heart rate, cardiac contractility, and peripheral vascular resistance are described, and the implication for targeting protein kinases in metabolic diseases is discussed.
MeSH terms
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Aminopyridines / chemical synthesis
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Aminopyridines / pharmacology
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Anesthesia
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Anesthetics
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Animals
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Blood Pressure / drug effects*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Heart Rate / drug effects*
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MAP Kinase Kinase 4 / antagonists & inhibitors*
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Male
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Metabolic Diseases / drug therapy*
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Metabolic Diseases / enzymology*
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Myocardial Contraction / drug effects*
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
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Thiopental / analogs & derivatives
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Vascular Resistance / drug effects*
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Ventricular Function, Left / drug effects
Substances
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Aminopyridines
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Anesthetics
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Enzyme Inhibitors
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thiobutabarbital
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MAP Kinase Kinase 4
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Thiopental