Abstract
Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a potent and selective way should offer new pharmacological tools and therapeutic agents.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Amidohydrolases / antagonists & inhibitors
-
Amidohydrolases / metabolism
-
Ceramidases
-
Enzyme Inhibitors / pharmacology*
-
Oxidoreductases / antagonists & inhibitors
-
Oxidoreductases / metabolism
-
Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
-
Phosphotransferases (Alcohol Group Acceptor) / metabolism
-
Serine C-Palmitoyltransferase / antagonists & inhibitors
-
Serine C-Palmitoyltransferase / metabolism
-
Sphingolipids / metabolism*
Substances
-
Enzyme Inhibitors
-
Sphingolipids
-
Oxidoreductases
-
dihydroceramide desaturase
-
Serine C-Palmitoyltransferase
-
Phosphotransferases (Alcohol Group Acceptor)
-
sphingosine kinase
-
ceramide kinase
-
Amidohydrolases
-
Ceramidases