Atrial peptides induce mast cell histamine release

Peptides. 1990 Sep-Oct;11(5):1003-7. doi: 10.1016/0196-9781(90)90024-y.

Abstract

Human atrial natriuretic peptide [ANF(1-28)] contains five arginine residues and carries an overall positive change of four. It was hypothesized that atrial peptides may induce mast cell histamine release. In vitro, three atrial peptides [ANF(1-28), (3-28) and (5-28)] were demonstrated to induce dose-dependent histamine release from isolated rat peritoneal mast cells. In vivo, ANF(3-28) produced a dose-dependent increase in rat skin permeability which was blocked by antagonists of histamine and serotonin. The results indicate atrial peptides are capable of inducing mast cell degranulation in a manner similar to that described for other positively charged peptides.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Atrial Natriuretic Factor / administration & dosage
  • Atrial Natriuretic Factor / pharmacology*
  • Dose-Response Relationship, Drug
  • Histamine Antagonists / pharmacology
  • Histamine Release / drug effects*
  • Injections, Intradermal
  • Male
  • Mast Cells / drug effects*
  • Molecular Sequence Data
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Serotonin Antagonists / pharmacology
  • Stimulation, Chemical
  • Structure-Activity Relationship
  • Substance P / pharmacology
  • p-Methoxy-N-methylphenethylamine / pharmacology

Substances

  • Histamine Antagonists
  • Peptide Fragments
  • Serotonin Antagonists
  • atrial natriuretic factor (3-28)
  • Substance P
  • p-Methoxy-N-methylphenethylamine
  • Atrial Natriuretic Factor
  • atrial natriuretic factor (5-28)