Erythromycin alters the pharmacokinetics of bromocriptine by inhibition of organic anion transporting polypeptide C-mediated uptake

Clin Pharmacol Ther. 2006 Oct;80(4):421-2. doi: 10.1016/j.clpt.2006.06.003.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Antiparkinson Agents / pharmacokinetics*
  • Bromocriptine / pharmacokinetics*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / drug effects
  • Cytochrome P-450 Enzyme System / metabolism
  • Dopamine Agonists / pharmacokinetics
  • Erythromycin / pharmacology*
  • Humans
  • Liver-Specific Organic Anion Transporter 1 / drug effects*
  • Liver-Specific Organic Anion Transporter 1 / metabolism*

Substances

  • Anti-Bacterial Agents
  • Antiparkinson Agents
  • Dopamine Agonists
  • Liver-Specific Organic Anion Transporter 1
  • Bromocriptine
  • Erythromycin
  • Cytochrome P-450 Enzyme System
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human