Abstract
The i.p. injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) caused hypothermia and increased the concentrations of serum corticosterone and plasma ACTH in mice. The effects of 8-OH-DPAT at a dose of 2 mg/kg but not of 0.2 mg/kg on the hormone levels were attenuated by pretreatment with p-chlorophenylalanine (pCPA) which depleted brain 5-HT by about 70%; the hypothermic effect of 8-OH-DPAT was, however, not prevented. Similar results were obtained with another 5-HT1A agonist, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Adrenal Cortex / drug effects*
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Adrenal Cortex / physiology
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Adrenocorticotropic Hormone / blood
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Animals
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Corticosterone / blood
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Fenclonine / pharmacology*
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Hydroxyindoleacetic Acid / blood
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Male
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Mice
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Mice, Inbred Strains
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Piperazines / pharmacology
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Pituitary Gland / drug effects*
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Pituitary Gland / physiology
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Receptors, Serotonin / physiology*
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Serotonin / blood
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Tetrahydronaphthalenes / pharmacology
Substances
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Piperazines
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Receptors, Serotonin
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Tetrahydronaphthalenes
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Serotonin
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Hydroxyindoleacetic Acid
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8-Hydroxy-2-(di-n-propylamino)tetralin
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BP 554
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Adrenocorticotropic Hormone
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Fenclonine
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Corticosterone