Abstract
This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Calcium / metabolism
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Calcium Channel Blockers / chemical synthesis
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Calcium Channel Blockers / chemistry*
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Calcium Channel Blockers / pharmacology
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Calcium Channels, T-Type
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Cell Cycle / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Drug Screening Assays, Antitumor
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Humans
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Neoplasms / drug therapy
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Neoplasms / pathology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Calcium Channel Blockers
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Calcium Channels, T-Type
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Calcium