Abstract
Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Angiogenesis Inhibitors / chemical synthesis*
-
Angiogenesis Inhibitors / chemistry
-
Angiogenesis Inhibitors / pharmacology*
-
Cells, Cultured
-
Cyclooxygenase 1 / metabolism*
-
Cyclooxygenase Inhibitors / chemical synthesis*
-
Cyclooxygenase Inhibitors / chemistry
-
Cyclooxygenase Inhibitors / pharmacology*
-
Endothelial Cells / drug effects
-
Humans
-
Molecular Structure
-
Structure-Activity Relationship
-
Umbilical Cord / drug effects
Substances
-
Angiogenesis Inhibitors
-
Cyclooxygenase Inhibitors
-
Cyclooxygenase 1