Abstract
High-throughput screening revealed compound 1 as a potent antagonist of the CCK(1) receptor. Here, we disclose the synthesis of combinatorial libraries by solid-phase synthesis on Kenner 'safety catch' resin. Additive QSAR models were used to determine a lack of consistent additive SAR within the matrix.
MeSH terms
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Chemistry, Pharmaceutical / methods*
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Cholecystokinin / chemistry
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Combinatorial Chemistry Techniques
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Humans
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Hydrogen-Ion Concentration
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Models, Chemical
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Models, Statistical
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Peptide Library
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Pharmaceutical Preparations / chemistry
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Protein Binding
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Pyrazoles / chemistry*
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Receptor, Cholecystokinin A / antagonists & inhibitors*
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Regression Analysis
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Structure-Activity Relationship
Substances
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Peptide Library
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Pharmaceutical Preparations
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Pyrazoles
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Receptor, Cholecystokinin A
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Cholecystokinin