Abstract
The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis / drug effects*
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Cell Survival / drug effects
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Humans
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Inflammation / drug therapy
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Inflammation / metabolism
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Ischemia / drug therapy
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Ischemia / metabolism*
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Neoplasms / drug therapy
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Neoplasms / metabolism*
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Phosphorylation / drug effects
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Protein Kinase Inhibitors / metabolism
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Protein Kinase Inhibitors / therapeutic use*
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Proto-Oncogene Proteins c-akt / antagonists & inhibitors*
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Proto-Oncogene Proteins c-akt / metabolism
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Proto-Oncogene Proteins c-pim-1 / antagonists & inhibitors*
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Proto-Oncogene Proteins c-pim-1 / metabolism
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Signal Transduction / drug effects*
Substances
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Protein Kinase Inhibitors
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Proto-Oncogene Proteins c-akt
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Proto-Oncogene Proteins c-pim-1