Abstract
The cyanine dye 3,3'-dipropyl-2,2'-thiadicarbocyanine iodide [diS-C3(5)] was found to be a potent inhibitor of endogenous respiration of Ehrlich ascites tumor cells. This effect is believed to involve both rotenone and uncoupler type actions of the dye on the electron transport system of the mitochondria.
MeSH terms
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Adenosine Triphosphatases / metabolism
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Animals
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Benzothiazoles
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Carbocyanines / pharmacology*
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Carcinoma, Ehrlich Tumor / metabolism*
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Dinitrophenols / pharmacology
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Electron Transport / drug effects
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Fluorides / pharmacology
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Kinetics
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Mice
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Mitochondria / drug effects
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Mitochondria / metabolism*
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Oligomycins / pharmacology
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Oxygen Consumption / drug effects*
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Quinolines / pharmacology*
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Rotenone / pharmacology
Substances
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Benzothiazoles
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Carbocyanines
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Dinitrophenols
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Oligomycins
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Quinolines
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Rotenone
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3,3'-dipropyl-2,2'-thiadicarbocyanine
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Adenosine Triphosphatases
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Fluorides